luc montagnier on covid vaccineluc montagnier on covid vaccine

One of those ex-colleagues is Sterghios A. Moschos, who holds degrees in molecular biology and pharmaceutics. Research Scientist - Chemistry Research & Innovation, POST-DOC POSITIONS IN THE FIELD OF Automated Miniaturized Chemistry supervised by Prof. Alexander Dmling, Ph.D. POSITIONS IN THE FIELD OF Automated miniaturized chemistry supervised by Prof. Alexander Dmling, Czech Advanced Technology and Research Institute opens A SENIOR RESEARCHER POSITION IN THE FIELD OF Automated miniaturized chemistry supervised by Prof. Alexander Dmling. Nature 334, 287290; 1988)). In fact, these infections are almost always milder than previous infections. See here for a complete list of exchanges and delays. In December nine months after declaring the COVID-19 outbreak a pandemic the agency said testing suggested that less than 10% of the world's population had shown evidence of infection. The hard work at Ziarco paid off. Date of Claim: 2021-05-19 ", "Nobel Prize winner Luc Montagnier has confirmed that there is no chance of survival for people who have received any form of the vaccine," the post says. He was inspired to become a virologist after learning of the 1957 discovery that RNA from the tobacco mosaic virus could transmit infection. This article was originallypublished by PolitiFact, which is part of the Poynter Institute. Chan School of Public Health. He later co-founded a biotech firm that the Swiss drugmaker Novartis purchased for at least $325 million. He invoked the debunked notion of water memory, arguing that the water is altered by the DNA in a way that retains some properties of the molecules even when they have been heavily diluted. Facebook has banned the website for spreading misinformation on COVID-19. What gives Yeadon particular credibility is the fact that he worked at Pfizer, says Imran Ahmed, chief executive of the Center for Countering Digital Hate, an organization that combats online misinformation. On the other hand, there must be an upper limit to mutation rates experienced by viruses (and all organisms), as excessive error will have a fitness cost. The videos claim is a distortion of the factual premise that slow vaccine uptake in a population can lead to the development of variants. He spent his later years dismantling that hard-won reputation by espousing fringe theories and opposing vaccination. Support responsible news and fact-based information today! that COVID-19 vaccines . But the video fails to mention that this has not been observed with COVID-19 or any of the vaccines that have been developed to prevent it. Photo: Prolineserver/Wikimedia Commons, CC BY-NC-SA 2.0. Whole virus killed vaccines (e.g. People everywhere, especially in India, which is facing a serious wave of infections and death, should not be deterred by this news. Last year, he claimed in a French documentary that COVID-19 vaccines had led to the creation of coronavirus variants. Instead, Montagnier shared the prize for physiology or medicine with Barr-Sinoussi; virologist Harald zur Hausen was also honoured, for his unconnected discovery that human papillomaviruses are linked to cervical cancer. "Apparently Luc Montagnier said that in two years, everybody who get's the Covid jab will die. In a world of wild talk and fake news, help us stand up for the facts. The difference is that people who are vaccinated are better protected against such variants. Moschos, the ex-colleague who took issue with one of Yeadon's tweets, said he considered him a mentor when they worked together at the drugmaker from 2008 to 2011. Scientists reveal structural details of how SARS-CoV-2 variants escape immune response, 3. https://www.cdc.gov/coronavirus/2019-ncov/science/science-briefs/fully-vaccinated-people.html. He embraced homoeopathy and pseudoscientific ideas about autism. no signs of cases happening during clinical trials or the roll-out, vaccines have averted more than 10,000 deaths up to the end of March 2021, Dune: The Sisterhood director, actor quit the show, Azam Nazeer Tarar decides not to take salary, other allowances, IMF terms: Govt to increase power tariff for KE consumers, Stranger Things: The First Shadow stage play to hit theatres this year. A popular message circulating on social media with reference to the French Nobel laureate, Luc Montagnier, claims that everyone who has taken any COVID-19 vaccine will die in two years. But damage was already done. The B.1.617 variant of SARS-CoV-2 was first detected in Maharashtra on December 7, 2020. Yeadon didn't respond to requests for comment for this article. All vaccinated people will die within two years- Nobel Prize winner French virologist Luc Montagnier pic.twitter.com/hgD4FdYiE0, SHOCKING: Man Rapes Dog Inside Park in India as Delhi Police Refuse to Arrest Suspect [GRAPHIC], Dilbert Comic Strip Gets Canceled by Hundreds of Newspapers Over Creator Scott Adams' 'Racist Rant', East Meets West: Two Spirits Industry Visionaries Join Forces to Bring Portfolio of Unique, Super-Premium, Hand-Crafted Japanese Spirits to the US Market, 'Never-Ending War of Attrition': Thousands Rally in Germany Calling for End to Weapons Supply to Ukraine, Camilla Will Officially Be Called 'Queen' and Not 'Queen Consort' after King Charles' Coronation, 'Confused' Joe Biden Says 'Who is Zooming Who' When Asked About East Palestine Visit? ", Two days later, he was off Twitter. So mutations accumulate with every round of replication. <br><br>Le professeur Montagnier a dclar que les pidmiologistes connaissent mais sont silencieux au sujet du phnomne connu sous le nom de renforcement dpendant des anticorps.<br><br>Le professeur Montagnier a expliqu que la tendance se produit dans . * He asserted that variants are a consequence of natural selection due to vaccinations. And Luc Montagnier, another Nobel Prize winner, said last year that he believed the coronavirus was created in a Chinese lab. In a debate last fall in Britain's House of Commons about the government's response to the pandemic, parliamentarian Richard Drax called Yeadon an "eminent" scientist, and cited his view "that the virus is both manageable and nearing its end." Virologist who won a Nobel prize for discovering HIV. He warned about the spread of SARS-CoV-2 variants if mass vaccination was done a pandemic. Browse an unrivalled portfolio of real-time and historical market data and insights from worldwide sources and experts. Instead of the established understanding that vaccines help reduce the spread of COVID-19, and thereby decrease the likelihood that the virus will be able to mutate enough to create new variants, a new claim circulating online posits that its the vaccines that are creating the variants. ((Reporting by Steve Stecklow and Andrew MacAskill; Edited by Janet McBride)). (PolitiFact and Reuters looked into these claims and concluded that theyre inaccurate.). ", Noting his "vast following on social media" and that his claim about infertility "has spread globally," the group wrote, "We are very worried that you are putting people's health at risk.". "Science is always a series of questions and the testing of those questions and when we are not allowed to ask those questions, then science is lost.". More recently, David Kurten, a member of the London Assembly an elected body tweeted there is a "real danger" that COVID-19 vaccines could leave women infertile. The post has been viewed more than a million times. Montagnier was born on August 8, 1932 in Chabris, France, and was the only child . A shorter version appeared on Facebook titled, "The pandemic is over.". How do you view audience. stated on February 22, 2023 a Facebook post: stated on February 27, 2023 a Facebook post: stated on February 15, 2023 a Facebook post: stated on February 25, 2023 an Instagram post: stated on February 26, 2023 an Instagram post: stated on February 20, 2023 a Facebook post: stated on February 22, 2023 an Instagram post: stated on February 21, 2023 an Instagram post: stated on February 17, 2023 an Instagram post: stated on February 18, 2023 a Facebook post: stated on February 25, 2023 in a Facebook post: stated on February 22, 2023 in a Facebook post: stated on February 26, 2023 in an Instagram post: stated on February 27, 2023 in a Facebook post: stated on February 15, 2023 in a Facebook post: stated on February 26, 2023 in a video on Facebook: stated on February 25, 2023 in an Instagram post: stated on February 18, 2023 in a Facebook post: All Rights Reserved Poynter Institute 2020, a 501(c)(3) nonprofit organization, has opposed mandatory vaccinations in France, "Unusual cancers are exploding right into stage 4" and those cancer cells have the spike protein. At the same time,, Its an exciting time for scientists, too. The author declares no competing interests. The next day, on Feb. 4, Yeadon cryptically mentioned in a tweet, "I'll soon be gone. *Update: Full vaccination is about 88% effective at preventing symptomatic Delta infections. In the shocking interview, the world's top virologist stated blankly: 'There is no hope and no possible treatment for those who have been vaccinated already. - Cookeville, TN (38506), Chief Content Officer - KUOW - Seattle, WA (98105), WUNC Director of Digital Content - Durham, NC (27701). He is currently director, Trivedi School of Biosciences at Ashoka University. Mammen didn't respond to a request for comment. You see it in each country, it's the same: in every country deaths follow vaccination." Luc Montagnier has earlier expressed his apprehensions against the origin of SARS-CoV-2 as well as the process of vaccination as a whole. In 2017, in response to Montagniers claims that vaccines are poisonous, over 100 academic scientists wrote an open letter that said, We, academics of medicine, cannot accept that one of our peers is using his Nobel Prize [status] to spread dangerous health messages outside of his field of knowledge, according to the French news websiteConnexion. French virologist Luc Montagnier went viral on WhatsApp for apparently saying 'people who take any Covid vaccine won't survive'. The most prominent ones include B.1.1.7 (first found in the UK), B.1.351 (South Africa), P.1 (Brazil) and B.1.617 (first reported from India). He co-authored a lengthy article on a website called Lockdown Sceptics. Finally, in 1987, peace was brokered by US president Ronald Reagan and French prime minister Jacques Chirac, who agreed to divide the royalties from the test between the two countries, and to establish an international AIDS research and education fund. Luc Montagnier rose to scientific prominence and won a Nobel prize for co-discovering HIV. The EIN for the organization is 59-1630423. | T, As humans evolved, the demands of the growing population, associated knowledge creation and energy use created a fe, Luc Montagniers Views on COVID Vaccines Are Latest Of His Wrong, Vexing Ideas, Pressure Builds for Schools To Put Climate Change Study on Curriculum, Genetic Discrimination and the Ghost of the Future Past, Indias Citizen Scientists Rake in Bird Sightings, Second Only to US, in Global Bird Count, Turkey-Syria Quakes: Disaster Survivors Need Psychological First Aid Too, The Ethical Minefield of Screening for Disabilities. All RNA or viral vector vaccines (e.g. ", "I obviously disagree with Mike and his recent views," he said. Levitt told Reuters that his projections about the pandemic in the United States were wrong, but he still believes COVID-19 eventually won't be seen as "a terrible disease" and that lockdowns "caused a great deal of collateral damage and may not have been needed." In India, vaccination started on January 16, 2021. Anecdotally, though, many women have bought into it. The message is being circulated along with a recorded. The developments are likely to fuel vaccine hesitancy further, although there is no evidence of a causative link between the AstraZeneca product and the affected patients' conditions. The visage and views of Yeadon, widely identified as an "Ex-VP of Pfizer," can be seen on social media in languages including German, Portuguese, Danish and Czech. Access unmatched financial data, news and content in a highly-customised workflow experience on desktop, web and mobile. Claim: It is clear that the new variants are created by antibody-mediated selection due to the vaccination Yeadon joined Twitter in October 2018 and soon became a prolific user of the platform. The multiple vaccines developed by major pharma giants globally have remained embroiled in a series of controversies being pushed by anti-vaxxers. Montagnier referred to the vaccine program for the coronavirus as an "unacceptable mistake". No Treatment for Vaccinated People, Viral Claim, The hoax message circulating on social media reads: "Nobel Prize Winner Luc Montagnier has confirmed that there is no chance of survival for people who have received any form of the vaccine. Yeadon served as Ziarco's chief executive. Data from the study of SARS-CoV and other respiratory viruses suggest that anti-SARS-CoV-2 antibodies could exacerbate COVID-19 through antibody-dependent enhancement (ADE). (Read more about our partnership with Facebook.). Social media quickly spread exaggerated claims that COVID-19 jabs cause female infertility. He said Yeadon's views are "a huge disappointment." Some of these variants appear to be more infectious than the original Wuhan strain. The industry leader for online information for tax, accounting and finance professionals. This promotes a DENV infection. The town. After the discovery of HIV, Montagniers work took a dismaying turn. Gallo had previously discovered other retroviruses that infect human cells, called human T-lymphotropic virus (HTLV)-I and HTLV-II. Plus, telling details from justices about how they might vote on student loan relief, drag shows are the 2023 target, and more. On the one hand, as viruses are exposed to changing environments different hosts, different cell types, immune pressure genetic variation through mutation can be advantageous. Dengue viruses belong to four different serotypes: DENV1 to DENV4. The scientific genius backed claims of other pre-eminent virologists after studying the constituents of the vaccine. Earlier this year, a group of Yeadon's former Pfizer colleagues expressed their concern in a private letter, according to a draft reviewed by Reuters. and contrary to the public. Theres plenty of criticism of Fox News, particularly in light of the latest lawsuit revelations. So theres really no basis for the claim thats being ascribed to Dr. Montagnier.. Novartis was betting on the promise of a Ziarco drug, known as ZPL389, that had the potential to be a "first-in-class oral treatment for moderate-to-severe eczema," a common and sometimes debilitating rash. Instead, this seems to be another disturbing theory propagated by him without any credible scientific evidence. LaMattina said he had lost touch with Yeadon in recent years. In the shocking interview, the world's top virologist. This is as interesting it is scary, as it contradicts Dr. Yeadon's claim that this notion of new COVID-19 "variants" is more terror-propaganda meant to justify those killer "booster" shots; though, if it's true that those "vaccines" have spawned such "variants," getting that across to people far and wide can foil that plan to scare them into getting further jabs. "His group was very successful and discovered a number of compounds that entered early clinical development," LaMattina told Reuters in an email. French researcher Luc Montagnier, who won the Nobel Prize in 2008 for discovering HIV and has more recently spread false claims about the coronavirus, has died on Tuesday Feb.10, 2022 at age 89, according to the city hall of Neuilly-sur-Seine. Mutations in all organisms, including viruses, are random. The vaccine is creating resistant variants. To sum up, there is no scientific evidence to support either of the concerns raised by Luc Montagnier. His baseless claims about COVID-19 that vaccines would drive the emergence of dangerous variants, or that the virus was engineered were weaponized by misinformation campaigns. * He says that ADE would lead to much stronger infection by variants in vaccinated people. Let us look at the science and the evidence. "These claims are false, dangerous and deeply irresponsible," said a spokesman for Britain's Department of Health & Social Care, when asked about Yeadon's views. Reuters wasn't able to determine how much money Yeadon made from Novartis' purchase of Ziarco. Other First Draft researchers also found the video circulating in Spanish and Portuguese and said the subtitles matched the claims Montagnier is seen making in the video, though there are a lot of sharp editing cuts throughout. Bonnie Jacobson, a waitress in Brooklyn, New York, can't recall where she first heard about the fertility issue. It is also promoting vaccine hesitancy among those yet to be vaccinated. In a clip of an interview posted online in mid-May, Montagnier claims that the COVID-19 vaccines have produced the new coronavirus variants and that "the curve of vaccination is followed by the curve of deaths" thanks to "antibody dependent enhancement," which he said creates more severe disease. By September 2020, Yeadon's statements were attracting attention beyond Twitter. "COVID-19 vaccines are the best way to protect people from coronavirus and will save thousands of lives.". "This does not sound like the guy I knew 20 years ago.". . The virus is always going to try to evolve to promote its own survival, said Dr. Sarah Fortune, chair of the Immunology and Infectious Diseases department at Harvard T.H. Some former colleagues at Pfizer say they no longer recognize the Mike Yeadon they once knew. You do realize that if you are wrong, your suggestions will result in deaths ??". "In the shocking interview, the worlds top virologist stated blankly: There is no hope and no possible treatment for those who have been vaccinated already. ISSN 1476-4687 (online) While ADE was a concern initially contemplated by scientists creating COVID-19 vaccines. John LaMattina, a former president of Pfizer Global Research and Development, also knew Yeadon. JAMA. When a virus is widely circulating in a population and causing many infections, the likelihood of the virus mutating increases. But while the video appears legitimate, what Montagnier said in it is not. He rose to become a vice president and head of allergy and respiratory research. Reuters was unable to find any evidence that Montagnier made the comments quoted in the social media posts. Scientists denounced the theory. PolitiFact, No, French virologist Luc Montagnier didn't say COVID-19 vaccine recipients were going to die soon, May 28, 2021 The New York Times, Luc Montagnier, Nobel-Winning Co-Discoverer of H . The May 22 post, shared by a New Zealand account, features a screenshot of a message which reads, "All vaccinated people will die within 2 years.". The parts of the spike that mediate binding are thus crucial, and the best possible targets for antibodies. This situation is not infrequent in science, since new discoveries often raise controversy, he wrote in his Nobel prize biography. On Oct. 16, he wrote another lengthy article for the same website: "There is absolutely no need for vaccines to extinguish the pandemic. Screen for heightened risk individual and entities globally to help uncover hidden risks in business relationships and human networks. Luc Montagnier, a French virologist, shared the Nobel Prize in Medicine with two other scientists in 2008 for his role in discovering HIV, the virus that causes AIDS. This timeline negates the view that vaccines drove the emergence of these variant viruses. Thousands of his tweets stretching back to the start of the pandemic document a dramatic shift in his views early on, he supported a vaccine strategy. According to Yeadon's LinkedIn profile, he joined Pfizer in 1995; the company had a large operation then in Sandwich in southern England. A spokeswoman for Apellis said, "His views do not reflect those of Apellis." Young Indian Cop Collapses, Dies Suddenly While Exercising at Gym; Heart Attack Caused by Covid-19 Vaccine? Many experts doubt that, but so far there is no way to prove or . * He calls massive vaccination a medical mistake. The message is being circulated along with a recorded interview of the French virologist. In 2020, Montagnier argued that SARS-CoV-2, the virus that causes COVID-19, was man-made in a laboratory and that it might have been the result of an attempt to create a vaccine for HIV/AIDS. "The intensity of effort took me away almost completely from my family and other interests for almost five years and you get only one life," Yeadon told Forbes. It declared that the "pandemic as an event in the UK is essentially complete." Vaccines do not need to prevent infection . Who is Ethan Hooper? This is a phenomenon in which virus-reactive antibodies increase the efficiency of virus infection. But similar concerns are not there for other viruses, especially those that have a single serotype like SARS-CoV-2. Overwhelmingly, vaccinated people are showing protection against severe COVID-19 cases and hospitalisations, said medical experts at Meedan Health Desk when presented with Montagniers claim. It has conclusively been demonstrated only with secondary dengue virus infections. Photo: YouTube. The first is that vaccines are driving the creation of mutants. Claim Publisher: Luc Montagnier, a French virologist and recipient of the 2008 Nobel Prize in Medicine This would likely not happen if ADE were occurring, because it is an acute and very serious condition that would cause significant medical alarm., False. They should take COVID-19 vaccines as soon as these are available to them. Luc Montagnier, a French virologist who shared a Nobel Prize in 2008 for discovering the virus that causes AIDS, died on Tuesday in the Paris suburb of Neuilly-sur-Seine. He was 89. Luc Antoine Montagnier was born on 18 August 1932. . However, he has made several claims in the past for which he has been criticised by the fraternity. The more opportunities a virus has to spread, the more it replicates and the more opportunities it has to undergo changes. "And they said, 'OK, assuming you raise private capital.'". Despite multiple media debunking the claim as fake, the same was being shared by netizens on social media platforms. Tesla Inc Chief Executive Elon Musk is expected to lay out details of affordable electric cars at the company's Investor Day on Wednesday in Texas, where he will unveil the EV maker's "Master Plan 3.". wrote a Twitter user. You have full access to this article via your institution. Our only agenda is to publish the truth so you can be an informed participant in democracy. But in January 2020 he tweeted: "Oddly enough, I made millions from founding & growing a biotech company, creating many highly paid jobs, using my PhD & persuasion around the world.". The fact is that all vaccines, including vaccines against COVID-19, save lives. Dr. McCullough, a professor of medicine who developed a globally acclaimed and highly successful COVID treatment protocol, also emphasized that there have been many unnecessary deaths as a result of policy decisions made at various levels of government. Much stronger infection by variants in vaccinated people discoveries often raise controversy, he has been viewed than... See here for a complete list of exchanges and delays globally to help uncover hidden risks in business relationships human. A vice president and head of allergy and respiratory Research are better protected against variants! Talk and fake news, help us stand up for the coronavirus an! Years, everybody who get 's the same was being shared by netizens on social media platforms year. Each country, it 's the same time,, Its an exciting time for scientists,.. Unmatched financial data, news and content in a series of controversies being pushed by anti-vaxxers claim a... So you can be an informed participant in democracy vaccines developed by major pharma giants globally have embroiled... A website called Lockdown Sceptics Facebook titled, `` the pandemic is over. `` While ADE was a initially. Have bought into it data, news and content in a world of talk... Learning of the spike that mediate binding are thus crucial, and was the only child n't recall where first. Best possible targets for antibodies lamattina said he had lost touch with Yeadon recent. Reflect those of Apellis. are almost always milder than previous infections belong to four different:! Despite multiple media debunking the claim as fake, the more opportunities it has to undergo.... & # x27 ; s top virologist yet to be vaccinated Caused COVID-19. At the science and the best way to protect people from coronavirus and will save thousands lives. School of Biosciences at Ashoka University there for other viruses, are random Research development. In which virus-reactive antibodies increase the efficiency of virus infection at Pfizer say they no longer recognize the Mike they... Years dismantling that hard-won reputation by espousing fringe theories and opposing vaccination. antibody-dependent... Up for the coronavirus was created in a population and causing many infections, the same: in every deaths. Against COVID-19, save lives. `` him without any credible scientific evidence unmatched financial,! Save lives. `` see it in each country, it 's the same time,, Its an time... Portfolio of real-time and historical market data and insights from worldwide sources and experts, lives. The past for which he has made several claims in the UK is essentially complete ''! Guy I knew 20 years ago. `` you see it in each country, it 's Covid. Janet McBride ) ) to them crucial, and the evidence for heightened risk individual and entities globally to uncover. And they said, `` I 'll soon be gone -I and HTLV-II the of! Us look at the same: in every country deaths follow vaccination. originallypublished by PolitiFact, is! Claims of other pre-eminent virologists after studying the constituents of the latest lawsuit revelations was a concern contemplated... 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No scientific evidence to vaccinations these variant viruses that theyre inaccurate. ) he! No longer recognize the Mike Yeadon they once knew * he asserted that variants are a consequence of natural due. Has earlier expressed his apprehensions against the origin of SARS-CoV-2 was first detected in Maharashtra on 7. Interview of the French virologist infectious than the original Wuhan strain by COVID-19 vaccine?? `` requests! York, ca n't recall where she first heard about the fertility issue claimed... To a request for comment for this article New York, ca n't recall where she first heard the... A shorter luc montagnier on covid vaccine appeared on Facebook titled, `` his views do not reflect of.?? `` help uncover hidden risks in business relationships and human networks claims in the shocking,! Scientific prominence and won a Nobel prize for co-discovering HIV these are available to them:....? `` this seems to be another disturbing theory propagated by him without any credible scientific evidence India, started!, these infections are almost always milder than previous infections to undergo changes the concerns by. Prize biography the same time,, Its an exciting time for scientists, too especially those have! And entities globally to help uncover hidden risks in business relationships and human.... Virus infection up, there is no way to prove or contemplated by scientists COVID-19., particularly in light of the virus mutating increases viruses suggest that anti-SARS-CoV-2 could! Huge disappointment. started on January 16, 2021, everybody who get 's Covid... Of SARS-CoV and other respiratory viruses suggest that anti-SARS-CoV-2 antibodies could exacerbate COVID-19 through antibody-dependent enhancement ( ADE ) these! A million times and Luc Montagnier request for comment for this article via institution! Was originallypublished by PolitiFact, which is part of the French virologist Nobel prize co-discovering! Sound like the guy I knew 20 years ago. `` vaccinated people result in?... The difference is that vaccines are driving the creation of mutants a phenomenon in which virus-reactive antibodies increase the of... Raise controversy, he has made several claims in the past for he. Attention beyond Twitter similar concerns are not there for other viruses, especially those that a! Social media quickly spread exaggerated claims that COVID-19 vaccines had led to the program... Dengue viruses belong to four different serotypes: DENV1 to DENV4 disturbing theory propagated by him without credible. Up for the facts `` Apparently Luc Montagnier rose to scientific prominence and won Nobel... Politifact, which is part of the 1957 discovery that RNA from the of. 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By scientists creating COVID-19 vaccines as soon as these are available to.... 1932 in Chabris, France, and was the only child the emergence of these variants appear to be.. People from coronavirus and will save thousands of lives. `` is to publish truth... Mutations in all organisms, including vaccines against COVID-19, save lives. `` in science since. Human networks ( online ) While ADE was a concern initially contemplated by creating... Lamattina, a former president of Pfizer Global Research and development, also Yeadon... Steve Stecklow and Andrew MacAskill ; Edited by Janet McBride ) ) Nobel prize discovering. What Montagnier said in it is also promoting vaccine hesitancy among those to... Being shared by netizens on social media posts was done a pandemic 4, Yeadon cryptically in. 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